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869 .cirrhosis in the case of HBV and HCV infection), malignancy (hepatocellular carcinoma from the hepatitis viruses, posttransplant lym- phoproliferative disease due to the effects of EBV, squa- mous cell carcinoma from papillomavirus, and, probably, Kaposis sarcoma from HHV-8), or overt AIDS (from HIV infection); (c) 1015 of patients with relatively poor allograft function due to both acute and chronic rejection, who have received excessive amounts of immu- nosuppressive therapy, and who are often infected with one or more of the immunomodulating viruses-these pa- systwm, whom we have termed chronic neer-do-wells, are at the highest risk for life-threatening opportunistic infection caused by such agents as Cryptococcus neofor- mans, Pneumocystis carinii, Listeria monocytogenes, and Nocardia asteroides.
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